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Symbol
Name
ID

Gfi1
growth factor independent 1 transcription repressor
MGI:103170

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Neutropenia	B lymphocytopenia	Monocytosis	Acute myeloid leukemia
Disease(s) Associated with GFI1	Neutropenia	B lymphocytopenia	Monocytosis	Acute myeloid leukemia
acute myeloid leukemia
severe congenital neutropenia 2

Mouse Phenotypes

immune system phenotype

abnormal granulocyte differentiation

abnormal monocyte differentiation

abnormal T cell proliferation

decreased NK cell degranulation

small thymus

thymus hypoplasia

decreased thymocyte number

abnormal lymphopoiesis

abnormal NK cell differentiation

abnormal T cell differentiation

decreased double-negative T cell number

arrested T cell differentiation

abnormal myelopoiesis

decreased neutrophil cell number

absent neutrophils

decreased granulocyte number

abnormal neutrophil morphology

decreased B cell number

abnormal T cell subpopulation ratio

decreased T cell number

decreased lymphocyte cell number

increased monocyte cell number

abnormal monocyte morphology

abnormal NK cell physiology

abnormal T-helper 2 physiology

abnormal cytokine secretion

increased interleukin-1 beta secretion

increased interleukin-10 secretion

increased tumor necrosis factor secretion

increased susceptibility to endotoxin shock

Availability

Mouse Genotype

Gfi1^tm1.1Wep/Gfi1^tm1.1Wep

Gfi1^tm1Tmo/Gfi1^tm1Tmo

Gfi1^tm1Wep/Gfi1^tm1Wep

Gfi1^tm2Tmo/Gfi1^tm2Tmo

Gfi1^{tm3(Gfib1)Tmo}/Gfi1^{tm3(Gfib1)Tmo}

Gfi1^tm4Tmo/Gfi1^tm4Tmo

Gfi1^Gen/Gfi1⁺

*

Gfi1^tm1Wep/Gfi1^tm1Wep
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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